Potential Ebola Drug Target Identified in Mouse Study

Potential Ebola Drug Target Identified in Mouse Study

Potential Ebola Drug Target Identified in Mouse Study

Researchers zero in on a key protein involved in infection

SOURCE: mBio, news release, May 26, 2015

TUESDAY, May 26, 2015 (HealthDay News) -- Researchers working with rodents say they've pinpointed a potential target for drugs to fight Ebola.

Studies with mice revealed that a protein called Niemann-Pick C1 (NPC1) plays a critical role in Ebola's ability to infect a host.

Drugs that block this protein might prove effective against the deadly disease, according to the authors of the study in the May/June issue of the online journal mBio.

"The science behind the concept of blocking the interaction between NPC1 and the virus is solid. Now, it is just a matter of powering through and identifying drugs that can inhibit NPC1 and moving them forward," co-principal investigator John Dye Jr., chief of viral immunology at U.S. Army Medical Research Institute of Infectious Diseases, said in a journal news release.

Previous lab studies showed that Ebola enters host cells by binding directly to NPC1, and that blocking the virus from doing this prevents infection, the researchers say.

In this study, the researchers found that mice genetically altered to lack NPC1 were not infected nine days after exposure to Ebola.

The team then tested three NPC1 inhibitors in normal mice exposed to Ebola. Only two of the drugs provided minimal protection. While studies on animals often fails to produce similar results in humans, further research could lead to more effective drugs, the investigators said.

There is no U.S. Food and Drug Administration-approved treatment for Ebola, the virus that has killed more than 11,000 people in West Africa since last year. Treatments under development focus on attacking the virus. A drug that targets NPC1 would be the first host-based treatment approach, the study authors said.

More information

The U.S. Centers for Disease Control and Prevention has more about Ebola.

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