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Trial of KN026 in Patients With HER2-positive Advanced Malignant Breast Cancer a...

This is a first-in-human (FIH), open-label, phase 1 dose-escalation study of KN026 in subjects with HER2 positive advanced breast and...

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Safety and Efficacy of Tisotumab Vedotin Monotherapy & in Combination With Other...

This is an open label, multi-center trial of tisotumab vedotin monotherapy and in combination with bevacizumab, pembrolizumab, or carboplatin in...

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A Study of ZN-c5 in Subjects With Breast Cancer

This is a Phase 1/2, open-label, multicenter, dose-escalation and expansion study to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy...

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Phase II Study of Atezolizumab + Bevacizumab in Endometrial Cancer

This is a single arm, Phase II study using the combination of atezolizumab and bevicacizumab in women with advanced, recurrent...

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Efficacy of [18F]PSMA-1007 PET/CT in Patients With Biochemial Recurrent Prostate...

This study evaluates the diagnostic performance and safety of [18F]PSMA-1007 PET/CT imaging in patients with suspected recurrence of prostate cancer...

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Identifying and Measuring Depression in Older Cancer Patients

The purpose of this study is to develop an accurate and useful way of measuring older patients' moods and reactions...

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Study of HPN424 in Patients With Advanced Prostate Cancer

An open-label, Phase 1/2a, study of HPN424 as monotherapy to assess the safety, tolerability and PK in patients with advanced...

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Robotic, Laparoscopic and Open Surgery for Gastric Cancer Compared on Surgical,...

Gastric cancer represents a great challenge for health care providers and requires a multidisciplinary context in which surgery plays a...

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An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With...

The purpose of this study is to evaluate the objective response rate (complete response [CR]+ partial response [PR]) of the...

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A Phase I Gene Therapy Study of FP253/Fludarabine for Prostate Cancer

The primary objective of this study is to determine the safety and tolerability of a gene-directed enzyme prodrug therapy for...

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KORTUC Phase II - Intra-tumoural Radiation Sensitizer in Patients With Locally A...

This is a study aimed at testing a commonly available and inexpensive chemical (hydrogen peroxide) for efficacy in sensitising large...

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Oral EPI-7386 in Patients With Metastatic Castration-Resistant Prostate Cancer

This is a phase I, clinical research study of EPI-7386, an investigational drug being studied as a treatment for patients...

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Study of GLS-010 Injection in Patients With Recurrent or Metastatic Cervical Can...

Patients with recurrent or metastatic cervical cancer,and will be treated with GLS-010.

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Gevokizumab With Standard of Care Anti-cancer Therapies for Metastatic Colorecta...

This study will determine the pharmacodynamically-active dose of gevokizumab and the tolerable dose and preliminary efficacy of gevokizumab in combination...

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Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2+...

DESTINY-Gastric03 will investigate the safety, tolerability, pharmacokinetics, immunogenicity, and preliminary antitumor activity of trastuzumab deruxtecan (T-DXd) alone or ...

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A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therap...

This study will compare the efficacy and safety of molecularly-guided therapy versus standard platinum-containing chemotherapy in participants with poor-prognosis cancer...

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First-in-human Study of CCW702 in Patients With Metastatic Castration Resistant...

CCW702 is an investigational immunotherapy for prostate cancer. This is a two-part, first-in-human study to assess the safety and tolerability...

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Trial of ARV-110 in Patients With Metastatic Castration Resistant Prostate Cance...

Phase 1/2 dose escalation study to assess the safety and tolerability of ARV-110 in men with mCRPC who have progressed...

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A Study on the Safety and Efficacy of LAE001 in the Treatment of Metastatic Pros...

This study is a multicenter phase I/II study of the treatment of patients with metastatic prostate cancer. The objective of...

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A Study of Select Drug Combinations in Adult Patients With Advanced/Metastatic B...

A phase Ib, open-label platform study of select drug combinations chosen in order to characterize safety and tolerability of each...

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A Phase III Study of Fruquintinib in Combination With Paclitaxel in Second Line...

Fruquintinib once daily in 4 weeks treatment cycle (three weeks on and one week off) in combination with Paclitaxel 80mg/㎡(day1,...

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PalbocIclib in PreMenopausal Women With ER Positive/HER-2 Negative MetAstatic Br...

This is an open label, randomized, multicenter, international phase II study for premenopausal patients with hormone receptor positive, HER2 negative...

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Phase 1b Study to Evaluate ATP128, VSV-GP128 and BI 754091, in Patients With Sta...

This is a multi-center, non-randomised Phase 1b study to evaluate the safety and tolerability of ATP128 alone or in combination...

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Phase 1 Study of SL-172154 (SIRPα-Fc-CD40L) in Subjects With Ovarian Cancer

This is a Phase 1 first in human, open label, multi-center, dose escalation study to evaluate the safety, tolerability, PK,...

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A Multi-Center, Open-Label Study of Fruquintinib in Solid Tumors, Colorectal, an...

An open-label, dose escalation and expansion clinical trial to evaluate the safety, tolerability, and PK of fruquintinib in patients with...

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Study of REGN4018 Administered Alone or in Combination With Cemiplimab in Adult...

Primary Objectives In the Dose Escalation Phase: • To assess the safety and pharmacokinetics (PK)...

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Non-interventional, Prospective Study to Determine Prevalence of EGFR Mutations...

This prospective, multicountry, multicentre, non-interventional study plans to include patients who have undergone surgery for early-stage (IA to IIIB on...

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A Randomized Phase III Trial of Eribulin Compared to Standard Weekly Paclitaxel...

This is a two arm Phase III trial in first and second-line HER2 negative patients with locally recurrent or metastatic...

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Prevention of Colorectal Cancer Through Multiomics Blood Testing

The PREEMPT CRC study is a prospective multi-center observational study to validate a blood-based test for the early detection of...

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Study of Telisotuzumab Vedotin (ABBV-399) in Participants With Previously Treate...

This study is designed to identify the target Non-Small Cell Lung Cancer (NSCLC) population(s) that over express c-Met (c-Met+) best...

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A Phase I/II Clinical Study of SAF-189s in Non-small Cell Lung Cancer (NSCLC) Pa...

The study comprises two phases: phase I dose escalation (including PK run-in period and treatment period) and phase II study.

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Study of REGN5678 (Anti-PSMAxCD28) With Cemiplimab (Anti-PD-1) in Patients With...

The primary objectives of the study in Dose Escalation are to evaluate safety, tolerability, and pharmacokinetics (PK) of REGN5678 alone...

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Safety and Efficacy of Talactoferrin in Addition to Standard Chemotherapy in Pat...

The purpose of the study is to determine whether the combination of talactoferrin, carboplatin and paclitaxel improves progression free survival...

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A Study of Neoadjuvant/Adjuvant Durvalumab for the Treatment of Patients With Re...

This is a Phase III, randomized, double-blind, placebo-controlled, multi-center international study assessing the activity of durvalumab and chemotherapy administered prior...

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Study of Amivantamab, a Human Bispecific EGFR and cMet Antibody, in Participants...

The purpose of study is to evaluate the safety, pharmacokinetics, and preliminary efficacy of Amivantamab as a monotherapy and in...

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Study of Nivolumab in Combination With Ipilimumab or Standard of Care Chemothera...

The purpose of this study is to determine whether an investigational immunotherapy nivolumab in combination with ipilimumab or in combination...