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Durvalumab and Tremelimumab for Pediatric Malignancies

The purpose of the study is to determine the recommended dose of durvalumab and tremelimumab (immunotherapy drugs) in pediatric patients...

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Predictive Mini-bolus Fluid Responsiveness in Pediatric Septic Shock

Severe sepsis and septic shock remain of particular gravity in children with a current mortality of about 20 % ,...

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rVWF Pediatric and Adult Study

This study will evaluate the long-term safety and hemostatic efficacy of recombinant von Willebrand factor (rVWF) (vonicog alfa) prophylaxis in...

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AMG 334 20160172 Pediatric Migraine PK Study.

AMG 334 20160172 Pediatric Migraine PK Study.

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Efficacy Study With QIVc in Pediatric Subjects

This phase 3 clinical study is a randomized, observer-blind, multicenter study of QIVc versus a non-influenza vaccine in subjects 6...

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Telavancin Pediatric PK Study (Ages >3 Months to 17 Years)

This is a multicenter, open-label, single-dose pharmacokinetic (PK) study. Infants, children, and adolescents will receive a single 10 mg/kg dose...

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Pediatric Patients With Metabolic or Other Genetic Disorders

Background: Some patients with unusual genetic conditions are referred to the National Institutes of Health (NIH). They may not be...

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Hokusai Study in Pediatric Patients With Confirmed Venous Thromboembolism (VTE)

This is an event driven Phase 3, prospective, randomized, open-label, blinded endpoint evaluation (PROBE) parallel group study in subjects with...

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Observational Evaluation of Atopic Dermatitis in Pediatric Patients

Primary Objectives: - To describe the characteristics of pediatric patients with moderate to severe atopic ...

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Safety and Efficacy of Fingolimod in Pediatric Patients With Multiple Sclerosis

To evaluate the safety and efficacy of fingolimod vs. interferon beta-1a i.m. in pediatric patients with multiple sclerosis (MS)

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Evaluation of Biomarkers of Atopic Dermatitis in Pediatric Patients (PEDISTAD BI...

Primary Objective: To explore associations between biomarkers of atopic dermatitis (AD) and: -...

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A Study of Tildrakizumab in Pediatric Subjects With Chronic Plaque Psoriasis

The study has been designed with two components. Part A is an open label PK study followed by a randomized...

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67Cu-SARTATE™ Peptide Receptor Radionuclide Therapy Administered to Pediatric Pa...

The aim of this study is to evaluate the safety and efficacy of 67Cu-SARTATE in pediatric patients with high-risk neuroblastoma.

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Study of Safety and Efficacy of CFZ533 in Type 1 Diabetes Pediatric and Young Ad...

The study is a Phase 2, multicounty, multicenter, non-confirmatory, investigator- and subject masked, randomized, placebo-controlled study to evaluate the safety,...

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Efficacy and Safety of Erenumab in Pediatric Subjects With Episodic Migraine

This study will evaluate the efficacy and safety of erenumab in migraine prevention in children (6 to <12 years) and...

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Pharmacokinetic (PK), Pharmacodynamic (PD) and Tolerability of Osilodrostat in P...

Multicenter, open-label, non-comparative study to evaluate the pharmacokinetics, pharmacodynamics, and tolerability of osilodrostat in children and adolescent patients with ...

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Study of Etelcalceide in Pediatric Subjects With Secondary Hyperparathyroidism a...

Study of Etelcalcetide in Pediatric Subjects With Secondary Hyperparathyroidism and Chronic Kidney Disease on Hemodialysis

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Risk Factors, Clinical Characteristics and Outcomes of Acute Infection With Coro...

Patient are being asked to provide respiratory and blood samples for a clinical research study because the patients have a...

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Safety, Tolerability and Efficacy of TransCon hGH Weekly Versus Daily hGH in Chi...

This study is conducted in China only. The purpose is to demonstrate the efficacy and safety of once weekly dosing...

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CLCZ696B2319E1 OL Extension Study to Evaluate Long-term Safety of Sacubitril/Val...

The purpose of this study is to evaluate long-term safety and tolerability data in eligible CLCZ696B2319 (PANORAMA-HF) patients receiving open-label...

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Nanoparticle Albumin-Bound Rapamycin, Temozolomide, and Irinotecan Hydrochloride...

This phase I trial studies the side effects and best dose of nanoparticle albumin-bound rapamycin when given together with temozolomide...

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A Roll-over Study With Rilpivirine for Human Immunodeficiency Virus Type 1 (HIV-...

The purpose of this study is to provide continued access to rilpivirine (RPV) for participants who were treated with RPV...

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Study of Purified Vero Rabies Vaccine Compared With a Reference Rabies Vaccine a...

Primary Objective: To describe the immune response induced by VRVg-2 and Verorab vaccine at D14 (to assess the ...

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A Study to Evaluate the Safety, Tolerability, and Efficacy of BIIB017 (Peginterf...

This study will evaluate the safety, tolerability, and descriptive efficacy of BIIB017 in pediatric participants with relapsing-remitting multiple sclerosis (RRMS)...

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Immunogenicity and Safety of a Quadrivalent Meningococcal Conjugate Vaccine in I...

The primary objective of the study is to demonstrate the non-inferiority of the antibody responses to meningococcal serogroups A, C,...

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Safety and Immunogenicity of a Quadrivalent Meningococcal Conjugate Vaccine When...

Primary Objective: 1. To describe the antibody titers to the antigens (meningococcal serogroups A, C, Y, and ...

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Immunogenicity and Safety Study of a Quadrivalent Meningococcal Conjugate Vaccin...

The primary objective of the study is to demonstrate the non-inferiority of the antibody response against meningococcal serogroups A, C,...

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A Study to Assess the Safety, Tolerability and Preliminary Efficacy of ASP0367 (...

The primary purpose of this study is to evaluate the safety and tolerability of ASP0367. This study will also evaluate...

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Study to Evaluate the Efficacy and Safety of Dimethyl Fumarate (Tecfidera) and P...

The main objective of the study is to evaluate the efficacy of dimethyl fumarate (Tecfidera) and peginterferon beta-1a (Plegridy), both...

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A Safety Study of Ustekinumab in the Treatment of Pediatric Participants Aged 6...

The purpose of this study is to monitor the long-term safety of ustekinumab in pediatric participants (6 years to 17...

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Activity, Safety and Pharmacokinetics in Pediatric Subjects With Moderate and Se...

This open-label, single-arm, Phase II multi-center study will enroll approximately 42 subjects and investigate the activity, pharmacokinetics and safety of...

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Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antib...

Phase 1 - To evaluate the safety and tolerability of REGN10933+REGN10987 compared to placebo ...

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Phase 2 Study Evaluating Autologous CD30.CAR-T Cells in Patients With Relapsed/R...

This is a two-part, Phase 2, multicenter, open-label, single arm study to evaluate the safety and efficacy of autologous CD30.CAR-T...

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A Study of the Safety and Pharmacokinetics of Apixaban Versus Vitamin K Antagoni...

To investigate the safety and pharmacokinetics of apixaban in children with congenital or acquired heart disease who have a need...

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Study to Evaluate the Efficacy and Safety of 3 Fixed Doses of Intranasal Esketam...

The purpose of this study is to assess the efficacy of a single (first) dose of 3 fixed doses of...

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Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell Dis...

This study is a Phase 3, randomized, double-blind, placebo-controlled study of voxelotor in pediatric participants, aged ≥ 2 to <...

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BAX 111 rVWF in Pediatrics

The purpose of this study in pediatric participants (<18 years of age) with severe hereditary von Willebrand disease (VWD) is: ...

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Study Assessing CLENPIQ as Bowel Preparation for Pediatric Colonoscopy

Bowel preparation for pediatric colonoscopy.

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A Phase 2, Double Blind Study to Assess Dexlansoprazole Delayed-Release Capsules...

The purpose of this study is to assess the safety and effectiveness of treatment with once daily (QD) oral administration...

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A Phase 2 Study of Dexlansoprazole Delayed-Release Capsules to Treat Symptomatic...

The purpose of this study is to assess the safety and effectiveness of treatment with once daily (QD) oral administration...