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Durvalumab and Tremelimumab for Pediatric Malignancies

The purpose of the study is to determine the recommended dose of durvalumab and tremelimumab (immunotherapy drugs) in pediatric patients...

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Safety and Efficiency of Denosumab in Pediatric Subjects With Glucocorticoid-ind...

To evaluate the effect of denosumab on lumbar spine bone mineral density (BMD) Z-score as assessed by dual-energy X-ray absorptiometry...

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BAX 111 rVWF in Pediatrics

The purpose of this study in pediatric participants (<18 years of age) with severe hereditary von Willebrand disease (VWD) is: ...

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rVWF Pediatric and Adult Study

This study will evaluate the long-term safety and hemostatic efficacy of recombinant von Willebrand factor (rVWF) (vonicog alfa) prophylaxis in...

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Efficacy Study With QIVc in Pediatric Subjects

This phase 3 clinical study is a randomized, observer-blind, multicenter study of QIVc versus a non-influenza vaccine in subjects 6...

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Observational Evaluation of Atopic Dermatitis in Pediatric Patients

Primary Objectives: - To describe the characteristics of pediatric patients with moderate to severe atopic ...

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Pediatric Patients With Metabolic or Other Genetic Disorders

Background: Some patients with unusual genetic conditions are referred to the National Institutes of Health (NIH). They may not be...

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AMG 334 20160172 Pediatric Migraine PK Study.

AMG 334 20160172 Pediatric Migraine PK Study.

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Study to Evaluate a Single Dose of Apixaban in Pediatric Subjects at Risk for a...

CV185118 is a single dose Apixaban PK/PD study in pediatric subjects. The objective of this study is primarily to study...

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Telavancin Pediatric PK Study (Ages >3 Months to 17 Years)

This is a multicenter, open-label, single-dose pharmacokinetic (PK) study. Infants, children, and adolescents will receive a single 10 mg/kg dose...

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Vedolizumab IV in Pediatric Participants With Ulcerative Colitis (UC) or Crohn's...

The purpose of this study is to evaluate vedolizumab pharmacokinetics (PK), safety and tolerability in pediatric participants with moderately to...

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Study of Dose Confirmation and Safety of Crizanlizumab in Pediatric Sickle Cell...

The purpose of the Phase 2 CSEG101B2201 study is to confirm and to establish appropriate dosing and to evaluate the...

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Post-Authorization Safety, Tolerability and Immunogenicity Evaluation of HyQvia...

The purpose of the study is to acquire additional data on safety, tolerability and immunogenicity of HyQvia in pediatric (age...

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Phase I/II Study of Avelumab in Pediatric Cancer Subjects

This is a multi-center, open-label, international study to evaluate the dose, safety and tolerability, antitumor activity, pharmacokinetic and pharmacodynamics of...

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A Study of Risdiplam (RO7034067) in Adult and Pediatric Participants With Spinal...

This is a multi-center, exploratory, non-comparative, and open-label study to investigate the safety, tolerability, PK, and PK/PD relationship of risdiplam...

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Hokusai Study in Pediatric Patients With Confirmed Venous Thromboembolism (VTE)

This is an event driven Phase 3, prospective, randomized, open-label, blinded endpoint evaluation (PROBE) parallel group study in subjects with...

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Pharmacokinetic (PK), Pharmacodynamic (PD) and Tolerability of Osilodrostat in P...

Multicenter, open-label, non-comparative study to evaluate the pharmacokinetics, pharmacodynamics, and tolerability of osilodrostat in children and adolescent patients with ...

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Study of Etelcalceide in Pediatric Subjects With Secondary Hyperparathyroidism a...

Study of Etelcalcetide in Pediatric Subjects With Secondary Hyperparathyroidism and Chronic Kidney Disease on Hemodialysis

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Study of Efficacy, Safety and Tolerability of ACZ885 (Canakinumab) in Pediatric...

To determine the effect of canakinumab versus placebo on daily pain experienced by sickle cell anemia patients (Reduction of average...

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Nanoparticle Albumin-Bound Rapamycin, Temozolomide, and Irinotecan Hydrochloride...

This phase I trial studies the side effects and best dose of nanoparticle albumin-bound rapamycin when given together with temozolomide...

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Study in Japanese Pediatric Subjects With Short Bowel Syndrome (SBS) Who Are Dep...

The purpose of this study is to determine if an investigational treatment (teduglutide) is safe and effective in Japanese children...

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A Study to Evaluate the Safety, Tolerability, and Efficacy of BIIB017 (Peginterf...

This study will evaluate the safety, tolerability, and descriptive efficacy of BIIB017 in pediatric participants with relapsing-remitting multiple sclerosis (RRMS)...

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Long-term Safety With Vedolizumab Intravenous (IV) in Pediatric Participants Wit...

The purpose of this study is to determine the safety profile of long-term vedolizumab IV treatment in pediatric participants with...

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Study of Midazolam Hydrochloride Oromucosal Solution (MHOS/SHP615) in Pediatric...

The purpose of this study is to determine if the investigational treatment, MHOS/SHP615, is safe and effective in children with...

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Immunogenicity and Safety of a Quadrivalent Meningococcal Conjugate Vaccine in I...

The primary objective of the study is to demonstrate the non-inferiority of the antibody responses to meningococcal serogroups A, C,...

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Study of Pharmacokinetics, Activity and Safety of Ruxolitinib in Pediatric Patie...

The study is an open-label, single-arm, Phase I/II multi-center study to investigate the PK, activity and safety of ruxolitinib added...

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A Safety Study of Ustekinumab in the Treatment of Pediatric Participants Aged 12...

The purpose of this study is to monitor the long-term safety of ustekinumab in pediatric participants (12 years to 17...

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CLCZ696B2319E1 OL Extension Study to Evaluate Long-term Safety of Sacubitril/Val...

The purpose of this study is to evaluate long-term safety and tolerability data in eligible CLCZ696B2319 (PANORAMA-HF) patients receiving open-label...

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Effect of Ticagrelor vs. Placebo in the Reduction of Vaso-occlusive Crises in Pe...

The purpose of the study is to Evaluate the Effect of Ticagrelor versus Placebo in Reducing the Rate of Vaso-Occlusive...

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Study to Evaluate the Efficacy and Safety of Dimethyl Fumarate (Tecfidera) and P...

The main objective of the study is to evaluate the efficacy of dimethyl fumarate (Tecfidera) and peginterferon beta-1a (Plegridy), both...

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A Roll-over Study With Rilpivirine for Human Immunodeficiency Virus Type 1 (HIV-...

The purpose of this study is to provide continued access to rilpivirine (RPV) for participants who were treated with RPV...

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Safety and Immunogenicity of a Quadrivalent Meningococcal Conjugate Vaccine When...

The primary objective of this study is to describe the antibody titers against meningococcal serogroups A, C, Y, and W...

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Immunogenicity and Safety Study of a Quadrivalent Meningococcal Conjugate Vaccin...

The primary objective of the study is to demonstrate the non-inferiority of the antibody response against meningococcal serogroups A, C,...

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Open Label Study to Evaluate Safety, Tolerability and Efficacy of Evolocumab (AM...

To describe the safety and tolerability of 80 weeks of subcutaneous (SC) evolocumab (AMG 145) when added to standard of...

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A Study of the Safety and Pharmacokinetics of Apixaban Versus Vitamin K Antagoni...

To investigate the safety and pharmacokinetics of apixaban in children with congenital or acquired heart disease who have a need...

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Study to Evaluate the Efficacy and Safety of 3 Fixed Doses of Intranasal Esketam...

The purpose of this study is to assess the efficacy of a single (first) dose of 3 fixed doses of...

Not Yet Enrolling

A Study of Tildrakizumab in Pediatric Subjects With Chronic Plaque Psoriasis

The study has been designed with two components. Part A is an open label PK study followed by a randomized...

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Evaluation of Biomarkers of Atopic Dermatitis in Pediatric Patients (PEDISTAD BI...

Primary Objective: To explore associations between biomarkers of atopic dermatitis (AD) and: -...

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67Cu-SARTATE™ Peptide Receptor Radionuclide Therapy Administered to Pediatric Pa...

The aim of this study is to evaluate the safety and efficacy of 67Cu-SARTATE in pediatric patients with high-risk neuroblastoma.

Not Yet Enrolling

Activity, Safety and Pharmacokinetics in Pediatric Subjects With Moderate and Se...

This open-label, single-arm, Phase II multi-center study will enroll approximately 42 subjects and investigate the activity, pharmacokinetics and safety of...