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Completed

An Endometrial Cancer Study for Women With Recurrent or Persistent Endometrial C...

This is an open-label, multi-center, single-arm, two-period Phase 2 study. The study will investigate the efficacy of Sodium Cridanimod in...

Completed

A Phase 1 Trial of SHR3680 With or Without SHR3162 in Prostate Cancer

This is a multicenter, dose-escalation/expansion phase 1 trial to evaluate the safety, tolerability and efficacy of SHR3680 with or without...

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Not Yet Enrolling

A Study of Novel Anti-cancer Agents in Patients With Previously Untreated NSCLC

This study is designed to determine the efficacy and safety of durvalumab and/or novel oncology therapies, with or without chemotherapy,...

Not Yet Enrolling

An Efficacy and Safety Study of Niraparib in Men With Metastatic Castration-Resi...

The purpose of this study is to assess the efficacy, safety, and pharmacokinetics of niraparib in men with metastatic castration...

Not Yet Enrolling

Open-label PET Study With [11C]Osimertinib in Patients With EGFRm NSCLC and Brai...

This is an open-label, single centre, Phase I study to determine the brain exposure of [11C]osimertinib in patients with EGFRm...

Completed

Thromboprophylaxis With Rivaroxaban In Patients With Malignancy and Central Veno...

Purpose of Pilot Trial To determine the feasibility of conducting a multicentre randomized open label controlled trial evaluating the use...

Enrolling

Trial of KN026 in Patients With HER2-positive Advanced Malignant Breast Cancer a...

This is a first-in-human (FIH), open-label, phase 1 dose-escalation study of KN026 in subjects with HER2 positive advanced breast and...

Enrolling

Study of ONO-4538 in Gastric Cancer

The purpose of study is to evaluate the efficacy and safety of ONO-4538 with chemotherapy in unresectable advanced or recurrent...

Enrolling

Breath Analysis to Diagnose Lung Cancer

Determination of volatile organic compounds to discriminate patients with lung cancer from healthy smokers and non-smokers healthy subjects.

Enrolling

Safety and Efficacy of Tisotumab Vedotin Monotherapy & in Combination With Other...

This is an open label, multi-center trial of tisotumab vedotin monotherapy and in combination with bevacizumab, pembrolizumab, or carboplatin in...

Enrolling

An Open Label Study of Bavituximab and Pembrolizumab in Advanced Gastric and GEJ...

This study evaluates the combination of bavituximab and pembrolizumab in the treatment of gastric and gastroesphogeal cancer. All patients will...

Enrolling

Phase II Study of Atezolizumab + Bevacizumab in Endometrial Cancer

This is a single arm, Phase II study using the combination of atezolizumab and bevicacizumab in women with advanced, recurrent...

Enrolling

Study of Adjuvant ONO-4538 With Resected Gastric Cancer

The purpose of study is to evaluate the efficacy and safety of postoperative adjuvant chemotherapy with Nivolumab in combination with...

Enrolling

A Study of ZN-c5 in Participants With Breast Cancer

This is a Phase 1 open-label, multicenter study to evaluate biomarkers for ZN-c5 in subjects with breast cancer

Enrolling

A Study of ZN-c5 in Subjects With Breast Cancer

This is a Phase 1/2, open-label, multicenter, dose-escalation and expansion study to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy...

Enrolling

Vopratelimab and a CTLA-4 Inhibitor in PD-1/PD-L1 Inhibitor Experienced Subjects...

JTX-2011-201 is a Phase 2, open label clinical study of vopratelimab (JTX-2011) and ipilimumab in adult subjects with non-small cell...

Enrolling

A Pilot Study of BXCL701 in Patients With Pancreatic Cancer

A study to assess the biochemical and immunomodulatory effects of BXCL701 in pancreatic cancer.

Enrolling

A Study to Test Combination Treatments in Patients With Advanced Gastric Cancer

The purpose of this study is to determine whether Nivolumab in combination with other therapies is more effective than Nivolumab...

Enrolling

A Study of Neoadjuvant Nivolumab + Palbociclib + Anastrozole in Post-Menopausal...

A randomized multi-arm study evaluating the safety and efficacy of palbociclib and anastrozole with or without nivolumab in participants with...

Enrolling

Study of Talimogene Laherparepvec With Atezolizumab for Triple Negative Breast C...

Approximately 36 DLT-evaluable subjects will be enrolled in this study. The locations of the study will be in the United...

Enrolling

Study of NGM120 in Subjects With Advanced Solid Tumors and Pancreatic Cancer Usi...

Study of NGM120 in subjects with advanced solid tumors and pancreatic cancer.

Enrolling

Study of 18F-DCFPyL PET/CT Imaging in Patients With Suspected Recurrence of Pros...

This study evaluates the diagnostic performance and safety of 18F-DCFPyL (PyL) PET/CT imaging in patients with suspected recurrence of prostate...

Enrolling

Identifying and Measuring Depression in Older Cancer Patients

The purpose of this study is to develop an accurate and useful way of measuring older patients' moods and reactions...

Enrolling

Study of HPN424 in Patients With Advanced Prostate Cancer

An open-label, Phase 1, study of HPN424 as monotherapy to assess the safety, tolerability and PK in patients with advanced...

Enrolling

Clinical and Genetic Studies in Familial Non-medullary Thyroid Cancer

Background: - Researchers are studying types of thyroid cancer that seem to cluster in families. ...

Enrolling

Clinical Evaluation of a Test for Monitoring the Recurrence of Bladder Cancer

The objective of this study is to establish the performance characteristics of an assay that detects the recurrence of bladder...

Enrolling

Study of GLS-010 Injection in Patients With Recurrent or Metastatic Cervical Can...

Patients with recurrent or metastatic cervical cancer,and will be treated with GLS-010.

Enrolling

Study of Nivolumab Versus Placebo in Participants With High-Risk Breast Cancer

A randomized multi-arm study evaluating the efficacy and safety of nivolumab versus placebo in combination with neoadjuvant (pre-surgery)chemotherapy and adjuvant...

Enrolling

Study of IMP4297 in Patients With BRCA1/2 Mutation Ovarian Cancer

A phase II, multi-center, open-label, single-arm, non-randomized study to evaluate the efficacy, safety and tolerability of IMP4297 capsules in subjects...

Enrolling

Robotic, Laparoscopic and Open Surgery for Gastric Cancer Compared on Surgical,...

Gastric cancer represents a great challenge for health care providers and requires a multidisciplinary context in which surgery plays a...

Enrolling

A Phase I Gene Therapy Study of FP253/Fludarabine for Prostate Cancer

The primary objective of this study is to determine the safety and tolerability of a gene-directed enzyme prodrug therapy for...

Enrolling

Study of Nivolumab Plus Ipilimumab, Ipilimumab or Cabazitaxel in Men With Metast...

The purpose of this study is to determine whether Nivolumab plus Ipilimumab has preliminary evidence of safety and effectiveness in...

Enrolling

A Multi-Center Study of SM-88 in Subjects With Pancreatic Cancer

A prospective, open-label phase 2/3 trial in metastatic pancreatic cancer subjects who have failed two lines of prior systemic therapy....

Enrolling

A Study Of Avelumab In Combination With Other Cancer Immunotherapies In Advanced...

This is a Phase 1b/2 dose-optimization study to evaluate safety, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of avelumab (MSB0010718C) in...

Enrolling

KORTUC Phase II - Intra-tumoural Radiation Sensitizer in Patients With Locally A...

This is a study aimed at testing a commonly available and inexpensive chemical (hydrogen peroxide) for efficacy in sensitising large...

Enrolling

Oral EPI-7386 in Patients With Metastatic Castration-Resistant Prostate Cancer

This is a phase I, clinical research study of EPI-7386, an investigational drug being studied as a treatment for patients...

Enrolling

A Study of SHR3680 in Treating Patients With Hormone Sensitive Prostate Cancer

The aim of this study is to compare the safety and efficacy of SHR3680 with bicalutamide in the treatment of...

Enrolling

Gevokizumab With Standard of Care Anti-cancer Therapies for Metastatic Colorecta...

This study will determine the pharmacodynamically-active dose of gevokizumab and the tolerable dose and preliminary efficacy of gevokizumab in combination...

Enrolling

MEN1611 With Trastuzumab (+/- Fulvestrant) in Metastatic Breast Cancer

The main purpose of this open-label, dose-escalation, phase Ib study is to identify the appropriate dose of MEN1611 to be...

Enrolling

DS-8201a in Pre-treated HER2 Breast Cancer That Cannot be Surgically Removed or...

This study will compare DS 8201a to standard treatment. Participants must have HER2 breast cancer that has been treated before. ...

Enrolling

A Phase I Study of FCN-411 in Advanced Non-small Cell Lung Cancer Chinese Patien...

This phase I trial with dose-escalation stage and dose-expansion stage is the first-in-human study of FCN-411, a drug being developed...

Enrolling

An Investigational Immunotherapy Study of Nivolumab in Combination With Rucapari...

The purpose of this study is to assess the safety and efficacy of nivolumab in combination with rucaparib, docetaxel, or...

Enrolling

A Study of Abiraterone Acetate Plus Prednisone With or Without Abemaciclib (LY28...

This study is being done to see how safe and effective abemaciclib is when given together with abiraterone acetate plus...

Enrolling

Study of 2 Ribociclib Doses in Combination With Aromatase Inhibitors in Women Wi...

QT interval prolongation and neutropenia are considered to be important identified risks for ribociclib (Kisqali® Prescribing Information, Investigator Brochure). The...

Enrolling

A Study of IMP4297 as Maintenance Treatment Following First-line Chemotherapy in...

IMP4297 is a PARP inhibitor. This is a 2:1 randomized, double-blind, placebo-controlled study conducted in patients with advanced (FIGO Stage...

Enrolling

the Combination of GX-188E Vaccination and Pembrolizumab in Patients With HPV 16...

A Multi-Center, Open-label Phase Ib-II Trial of the Combination of GX-188E Vaccination and Pembrolizumab in Patients with Advanced, Non-Resectable HPV-Positive...

Enrolling

Study of REGN4018 Administered Alone or in Combination With Cemiplimab in Patien...

The primary objectives of the Dose Escalation Phase are to assess the safety and pharmacokinetics (PK) in order to determine...