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A Study of Efficacy and Safety of LAG525 in Combination With Spartalizumab, or W...

The purpose of this study is to assess the efficacy, safety, and PK characteristics of the following three combinations: i)...

Not Yet Enrolling

An Investigational Immuno-therapy Study of Temozolomide Plus Radiation Therapy W...

The purpose of this study is to evaluate patients with glioblastoma that is MGMT-methylated (the MGMT gene is altered by...

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A Study of Atezolizumab (Tecentriq) to Investigate Long-term Safety and Efficacy...

This is a Phase III/IV, single-arm, multicenter study of the long-term safety and efficacy of atezolizumab treatment in participants with...

Not Yet Enrolling

Safety and Efficacy of Vicriviroc (MK-7690) in Combination With Pembrolizumab (M...

This trial will evaluate the safety and efficacy of vicriviroc (MK-7690) at 2 dose levels in combination with pembrolizumab (MK-3475)...

Enrolling

Safety Study of SEA-CD40 in Cancer Patients

This study is being done to find out if SEA-CD40 is safe and effective when given alone, in combination with...

Enrolling

LTX-315 in Patients With Transdermally Accessible Tumours as Monotherapy or Comb...

The study will assess the safety, tolerability, PK and efficacy of different intra-tumoral dosing regimens of LTX-315; a lytic-peptide that...

Enrolling

A Study of APX3330 in Patients With Advanced Solid Tumors

This is a Phase 1, multi-center, open-label, dose-escalation oncology study of APX3330 in patients with advanced solid tumors.

Enrolling

An Investigational Immuno-Therapy Study of Experimental Medication BMS-986253 Gi...

The purpose of this study is to investigate experimental medication BMS-986253 in combination with Nivolumab in patients with advanced cancers.

Enrolling

A Dose Escalation and Combination Immunotherapy Study to Evaluate BMS-986226 Alo...

The purpose of this study is to investigate BMS-986226 administered alone or in combination with nivolumab or ipilimumab.

Enrolling

Study to Evaluate the Safety and Tolerability of RXC004 in Advanced Malignancies...

The purpose of Part A of this study is to determine the safety and tolerability of RXC004 in patients with...

Enrolling

Open-Label Extension and Safety Study of Talazoparib

This is a single-arm, open-label, extended treatment, safety study in patients treated with talazoparib in qualifying studies.

Enrolling

Safety Study of BMS-986016 With or Without Nivolumab in Patients With Advanced S...

This study will be used to determine the safety and tolerability of BMS-986016 administered alone and in combination with Nivolumab...

Enrolling

Oral AMXT 1501 Dicaprate in Combination With DFMO

A Phase 1 study will be conducted to establish safety and dose level of AMXT 1501 dicaprate alone, and in...

Enrolling

Thromboprophylaxis With Rivaroxaban In Patients With Malignancy and Central Veno...

Purpose of Pilot Trial To determine the feasibility of conducting a multicentre randomized open label controlled trial evaluating the use...

Enrolling

Vopratelimab and a CTLA-4 Inhibitor in PD-1/PD-L1 Inhibitor Experienced Subjects...

JTX-2011-201 is a Phase 2, open label clinical study of vopratelimab (JTX-2011) and ipilimumab in adult subjects with non-small cell...

Enrolling

A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary...

A study evaluating the safety, pharmacokinetics (PK), pharmacodynamics, and preliminary efficacy of ABBV-927 + ABBV-368 with and without ABBV-181 in...

Enrolling

A Study of Neoadjuvant Nivolumab + Abemaciclib or Palbociclib + Anastrozole in P...

A randomized multi-arm study evaluating the safety and efficacy of abemaciclib or palbociclib and anastrozole with or without nivolumab in...

Enrolling

Family Genetics Health Education and Healthy Behaviors

Background: - Family-based approaches to reduce disease risk and promote healthy behaviors may be better ...

Enrolling

Study of RP1 Monotherapy and RP1 in Combination With Nivolumab

RPL-001-16 is a Phase 1/2, open label, dose escalation and expansion clinical study of RP1 alone and in combination with...

Enrolling

Safety, Immunogenicity and Pharmacokinetics of SYN004 in Patients With Solid Tum...

A first-in-human evaluation of SYN004, a monoclonal antibody that binds to the EGF receptor on cancer cells. Cetuximab, a marketed...

Enrolling

Galinpepimut-S in Combination With Pembrolizumab in Patients With Selected Advan...

To evaluate the safety and tolerability of galinpepimut-S in combination with pembrolizumab in patients with selected advanced cancers. Patients will...

Enrolling

Vactosertib in Combination With Pembrolizumab in Metastatic Colorectal or Gastri...

This is an open-label, multicenter study to assess the safety, tolerability, pharmacokinetics, and antitumor activity of vactosertib in combination with...

Enrolling

Study of ImmunoPet Imaging of PD-L1 in Tumors Using 89Zr-DFO-REGN3504 in Patient...

The primary objective of the study is to determine the safety and tolerability of 89Zr-DFO-REGN3504. ...

Enrolling

Study of 18F-DCFPyL PET/CT Imaging in Patients With Suspected Recurrence of Pros...

This study evaluates the diagnostic performance and safety of 18F-DCFPyL (PyL) PET/CT imaging in patients with suspected recurrence of prostate...

Enrolling

Initiative for Molecular Profiling in Advanced Cancer Therapy (IMPACT) Trial, An...

Primary Objective The primary objective of this study is to establish a program for the molecular profiling of patients with...

Enrolling

Anti-Mullerian Hormone (AMH) as Marker of Ovarian Reserve

This is a multicentre, prospective study willing to evaluate AMH levels changes in response to chemotherapy plus GnRHa. ...

Enrolling

I-SPY 2 TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breas...

The purpose of this study is to further advance the ability to practice personalized medicine by learning which new drug...

Enrolling

An Investigational Immuno-therapy Study of Nivolumab Compared to Temozolomide, E...

The purpose of this study is to evaluate patients with glioblastoma that is MGMT-unmethylated (the MGMT gene is not altered...

Enrolling

A Study of rSIFN-co in Subjects With Advanced Solid Tumors

This is a multicenter, open-label, phase I study of rSIFN-co (3 times a week via subcutaneous injection for 21 days,...

Enrolling

A Study Evaluating Safety, Pharmacokinetics, and Therapeutic Activity of RO68742...

This first-in-human, open-label, multicenter, Phase Ia/Ib, adaptive, multiple ascending-dose study will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), ...

Enrolling

Phase II Study of Tipifarnib in Squamous Head and Neck Cancer With HRAS Mutation...

Phase II study to investigate the antitumor activity in terms of objective response rate (ORR) of tipifarnib in subjects with...

Enrolling

A Study Of Avelumab In Combination With Other Cancer Immunotherapies In Advanced...

This is a Phase 1b/2 dose-optimization study to evaluate safety, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of avelumab (MSB0010718C) in...

Enrolling

Phase 1/1b Study to Evaluate the Safety and Tolerability of Ciforadenant Alone a...

This is a phase 1/1b open-label, multicenter, dose-selection study of ciforadenant, an oral small molecule targeting the adenosine-A2A receptor on...

Enrolling

A Trial Comparing Cardiovascular Safety of Degarelix Versus Leuprolide in Patien...

The purpose of this trial is to test if a marketed drug for advanced prostate cancer (FIRMAGON) can reduce the...

Enrolling

An Investigational Immuno-therapy Study of BMS-986205 Given in Combination With...

The purpose of the study is to determine safety and effectiveness of experimental medication BMS-986205 when combined with Nivolumab and...

Enrolling

Study of ONO-4538 in Gastric Cancer

The purpose of study is to evaluate the efficacy and safety of ONO-4538 with chemotherapy in unresectable advanced or recurrent...

Enrolling

A Phase 1 Trial of SHR3680 With or Without SHR3162 in Prostate Cancer

This is a multicenter, dose-escalation/expansion phase 1 trial to evaluate the safety, tolerability and efficacy of SHR3680 with or without...

Enrolling

A Phase I/II Study of MEDI4736 in Combination With Olaparib in Patients With Adv...

The purpose of this study is to look at the effectiveness, safety, and antitumor activity of study drugs MEDI4736 in...