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A Study of APX3330 in Patients With Advanced Solid Tumors

This is a Phase 1, multi-center, open-label, dose-escalation oncology study of APX3330 in patients with advanced solid tumors.

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A Dose Escalation and Combination Immunotherapy Study to Evaluate BMS-986226 Alo...

The purpose of this study is to investigate BMS-986226 administered alone or in combination with nivolumab or ipilimumab.

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Study to Evaluate the Safety and Tolerability of RXC004 in Advanced Malignancies...

The purpose of Part A of this study is to determine the safety and tolerability of RXC004 in patients with...

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Open-Label Extension and Safety Study of Talazoparib

This is a single-arm, open-label, extended treatment, safety study in patients treated with talazoparib in qualifying studies.

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Safety Study of BMS-986016 With or Without Nivolumab in Patients With Advanced S...

This study will be used to determine the safety and tolerability of BMS-986016 administered alone and in combination with Nivolumab...

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An Investigational Immuno-Therapy Study of Experimental Medication BMS-986253 Gi...

The purpose of this study is to investigate experimental medication BMS-986253 in combination with Nivolumab in patients with advanced cancers.

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An Investigational Immuno-Therapy Study of Experimental Medication BMS-986277 Gi...

The purpose of this study is to investigate experimental medication BMS-986277 given alone and in combination with Nivolumab in patients...

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Study of RP1 Monotherapy and RP1 in Combination With Nivolumab

RPL-001-16 is a Phase 1/2, open label, dose escalation and expansion clinical study of RP1 alone and in combination with...

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A Study of MEDI1191 Alone and in Combination With Durvalumab in Subjects With Ad...

To evaluate MEDI1191 administered intratumorally alone and in combination with intravenous durvalumab in patients with solid tumors

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Vopratelimab and a CTLA-4 Inhibitor in PD-1/PD-L1 Inhibitor Experienced Subjects...

JTX-2011-201 is a Phase 2, open label clinical study of vopratelimab (JTX-2011) and ipilimumab in adult subjects with non-small cell...

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Safety Study of SEA-CD40 in Cancer Patients

This study is being done to find out if SEA-CD40 is safe and effective when given alone, in combination with...

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Thromboprophylaxis With Rivaroxaban In Patients With Malignancy and Central Veno...

Purpose of Pilot Trial To determine the feasibility of conducting a multicentre randomized open label controlled trial evaluating the use...

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A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary...

A study evaluating the safety, pharmacokinetics (PK), pharmacodynamics, and preliminary efficacy of ABBV-927 + ABBV-368 with and without ABBV-181 in...

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LTX-315 in Patients With Transdermally Accessible Tumours as Monotherapy or Comb...

The study will assess the safety, tolerability, PK and efficacy of different intra-tumoral dosing regimens of LTX-315; a lytic-peptide that...

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Family Genetics Health Education and Healthy Behaviors

Background: - Family-based approaches to reduce disease risk and promote healthy behaviors may be better ...

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Oral AMXT 1501 Dicaprate in Combination With DFMO

A Phase 1 study will be conducted to establish safety and dose level of AMXT 1501 dicaprate alone, and in...

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Safety, Immunogenicity and Pharmacokinetics of SYN004 in Patients With Solid Tum...

A first-in-human evaluation of SYN004, a monoclonal antibody that binds to the EGF receptor on cancer cells. Cetuximab, a marketed...

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Efficacy and Safety of Ribociclib in Pre- and Postmenopausal Chinese Women With...

This is a Phase II randomized, double-blind, placebo-controlled study involving premenopausal and postmenopausal Chinese women plus an open-label single arm...

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Sym021 Monotherapy and in Combination With Sym022 or Sym023 in Patients With Adv...

The primary purpose of this study is to see if Sym021 is safe and tolerable as monotherapy and in combination...

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Study of the Safety, Pharmacokinetics, and Antitumor Activity of AK105 in Subjec...

This study is to characterize the safety, tolerability, pharmacokinetics (PK), immunogenicity, pharmacodynamics (PD) and anti-tumor activity of AK105 as a...

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A Phase Ia/Ib Study of CS1001 in Advanced Solid Tumors

This is a phase Ia/Ib, open-label, multiple-dose, dose-escalation and expansion study to evaluate the safety, tolerability, pharmacokinetics and anti-tumor activity...

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Early and Accurate Detection of Prostate Cancer in General Practice

Prostate cancer (PC) is the most common malignancy (4500 new cases/year) and the second leading cause of cancer-associated mortality (1200...

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Clinical Study to Compare the Efficacy and to Evaluate the Safety and Immunogeni...

This is a Phase III, double-blind, randomized multicenter study to compare the efficacy and to evaluate the safety and immunogenicity...

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Study of Adjuvant ONO-4538 With Resected Gastric Cancer

The purpose of study is to evaluate the efficacy and safety of postoperative adjuvant chemotherapy with Nivolumab in combination with...

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A Study to Test Combination Treatments in People With Advanced Renal Cell Carcin...

The purpose of this study is to test the effectiveness and safety of various nivolumab combinations compared to nivolumab and...

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An Endometrial Cancer Study for Women With Recurrent or Persistent Endometrial C...

This is an open-label, multi-center, single-arm, two-period Phase 2 study. The study will investigate the efficacy of Sodium Cridanimod in...

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A Phase 1/2 Safety Study of Intratumorally Dosed INT230-6

This study evaluates the intratumoral administration of escalating doses of a novel, experimental drug, INT230-6. The study is being conducted...

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A Multi-Center Study of SM-88 in Subjects With Pancreatic Cancer

A prospective, open-label phase 2/3 trial in metastatic pancreatic cancer subjects who have failed two lines of prior systemic therapy....

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A Study of CS1003 in Subjects With Advanced Solid Tumors

This study will evaluate the safety, tolerability, pharmacokinetic profile and treatment effect of a new drug known as CS1003 in...

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Initiative for Molecular Profiling in Advanced Cancer Therapy (IMPACT) Trial, An...

Primary Objective The primary objective of this study is to establish a program for the molecular profiling of patients with...

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A Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands

This primary purpose of this study is to find the recommended dose of LGK974 as a single agent and in...

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A Study of PDR001 in Combination With LCL161, Everolimus or Panobinostat

The purpose of this study is to combine the PDR001 checkpoint inhibitor with several agents with immunomodulatory activity to identify...

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A Study to Test Combination Treatments in Patients With Advanced Gastric Cancer

The purpose of this study is to determine whether Nivolumab in combination with other therapies is more effective than Nivolumab...

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Phase I/Ib Study of NIS793 in Combination With PDR001 in Patients With Advanced...

To characterize the safety and tolerability of NIS793 as single agent and in combination with PDR001 and to identify recommended...

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An Investigational Immunotherapy Study of BMS-986299 Alone and in Combination Wi...

The purpose of this study is to determine whether BMS-986299 both by itself and in combination with Nivolumab and Ipilimumab...

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A Study of IMP4297 in Patients With Advanced Solid Tumors

This is a Phase I, first-in-human, open-label, dose-escalation study of IMP4297 administered orally once every day to patients with advanced...

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Phase 1 Dose Escalation Study of CGX1321 in Subjects With Advanced Gastrointesti...

This is a multi-center, open label, repeat dose, Phase 1 study consisting of a Dose Escalation Phase and a Dose...

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Subjects With Metastatic or Locally Advanced Solid Tumors, and Expansion Into Se...

This is a Phase 1/2, open-label study of AGEN1884 in combination with AGEN2034 in subjects with locally advanced, recurrent and/or...

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A Study to Assess the Antitumor Activity, Safety, Pharmacokinetics and Biomarker...

The purpose of this study is to determine the Objective Response Rate (ORR) of zolbetuzimab as a single agent as...

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the Combination of GX-188E Vaccination and Pembrolizumab in Patients With HPV 16...

A Multi-Center, Open-label Phase Ib-II Trial of the Combination of GX-188E Vaccination and Pembrolizumab in Patients with Advanced, Non-Resectable HPV-Positive...

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An Investigational Immunotherapy Study of BMS-986249 Alone and in Combination Wi...

The purpose of this study is to determine whether BMS-986249 both by itself and in combination with Nivolumab is safe...

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A Study of Nivolumab or Nivolumab Plus Experimental Medication BMS-986205 With o...

A study to evaluate Nivolumab or Nivolumab Plus Experimental Medication BMS-986205 with or without BCG in BCG-Unresponsive non-muscle invasive Bladder...

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A Study to Evaluate the Safety and Tolerability of AB154 in Participants With Ad...

This is a Phase 1, multicenter, open-label, dose-escalation study to evaluate the safety, tolerability, PK, PD, and clinical activity of...

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A Study of Abiraterone Acetate Plus Prednisone With or Without Abemaciclib (LY28...

This study is being done to see how safe and effective abemaciclib is when given together with abiraterone acetate plus...

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Robotic, Laparoscopic and Open Surgery for Gastric Cancer Compared on Surgical,...

Gastric cancer represents a great challenge for health care providers and requires a multidisciplinary context in which surgery plays a...

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CGX1321 in Subjects With Advanced Solid Tumors and CGX1321 With Pembrolizumab in...

This is a multicenter, open-label study conducted in two phases: Phase 1 consisting of a CGX1321 Single Agent Dose Escalation...

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An Investigational Study of Immunotherapy Combinations in Participants With Soli...

The purpose of this study is to investigate safety and anti-tumor activity of relatlimab combination therapy in solid cancers that...

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A Study of SY-1365 in Adult Patients With Advanced Solid Tumors

This study consists of two parts. Part 1 is a dose-escalation/safety evaluation to provisionally identify a dose and regimen of...

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Study of the Safety, Pharmacokinetics, and Antitumor Activity of AK104 in Subjec...

This study is to characterize the safety, tolerability, pharmacokinetics (PK), immunogenicity, pharmacodynamics (PD) and anti-tumor activity of AK104 as a...

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A Study of Non-Small Cell Lung Cancer (NSCLC) Patients Receiving Second-Line Niv...

The purpose of this study is to investigate the safety of patients in Asia with Non-Small Cell Lung Cancer (NSCLC)who...

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A Study of Talazoparib in Men With DNA Repair Defects and Metastatic Castration-...

The purpose of this international, phase 2, open-label, response rate study of talazoparib is to assess the efficacy and safety...

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A Study of Nivolumab in Patients With Hepatocellular Carcinoma Who Are at High R...

This study will investigate if nivolumab will improve recurrence-free survival (RFS) compared to placebo in participants with HCC who have...

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A Study of ZN-c5 in Subjects With Breast Cancer

This is a Phase I, open-label, multicenter, sequential dose-escalation and expansion study to evaluate the safety, tolerability, pharmacokinetics, and preliminary...