A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes

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About the study

The purpose of this study is to investigate weight reduction with macupatide and eloralintide, alone or in combination, in adult participants with obesity or overweight and with type 2 diabetes. Participation in the study will last about 48 weeks.
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Who can take part

You may be eligible to participate in the study if you meet the following criteria:

INCLUSION CRITERIA

Inclusion Criteria:


  1. Have type 2 diabetes
  2. Have an HbA1c ≥7.5% to ≤10.5% at screening
  3. Have been treated with any of the following, alone or in combination, for at least 3 months prior to screening

  1. Diet and exercise
  2. Stable dose of metformin
  3. Sodium-glucose cotransporter-2 (SGLT2) inhibitor
  4. Have had a stable body weight (<5% body weight gain and/or loss) for the 3 months prior to screening
  5. Have a BMI of 27 or greater at screening

EXCLUSION CRITERIA

Exclusion Criteria:


  1. Have any form of diabetes other than type 2 diabetes
  2. Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed >1 year prior to screening
  3. Have any of the following cardiovascular conditions within 3 months prior to screening:

  1. acute myocardial infarction
  2. cerebrovascular accident (stroke)
  3. unstable angina, or
  4. hospitalization due to congestive heart failure
  5. Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years, exceptions include

  1. basal or squamous cell skin cancer
  2. in situ carcinomas of the cervix, or
  3. in situ prostate cancer
  4. Have been prescribed any of the following receptor agonists (RA) or their combination for any indication within the last 6 months:

  1. amylin RA
  2. dual amylin and calcitonin RA
  3. glucagon-like peptide-1 receptor (GLP-1) RA
  4. glucose-dependent insulinotropic peptide (GIP)/GLP-1 RA
  5. GLP-1/glucagon (GCG) RAs, or
  6. GIP/GLP-1/GCG RAs
  7. Have used excluded antihyperglycemic medications within 3 months prior to screening (including, but not limited to, sulfonylureas, dipeptidyl peptidase-4 inhibitors, alpha-glucosidase inhibitors, thiazolidinediones, and meglitinides
  8. Have used insulin for diabetic control within the prior year (short term use in certain situations allowed

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Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply


Contact the study center to learn if this study is a good match for you.
Phone iconCall 317-615-4559Email iconEmail Study Center

Study Details


Contition
Obesity,Overweight,Diabetes Mellitus, Type 2
Age
18 - 75
Phase
PHASE2
Participants Needed
200
Est. Completion Date
May 31, 2027
Treatment Type
INTERVENTIONAL

Sponsor
Eli Lilly and Company
ClinicalTrials.gov NCT Identifier
NCT07215559
Study Number
J2V-MC-GZLF

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