Evaluation of IGM-2644 in Adults With Relapsed and/or Refractory Multiple Myeloma

Inclusion Criteria:

1. Adults > 18 years at time of consent
2. ECOG performance status of 0 or 1
3. Relapsed and/or refractory multiple myeloma after ≥ 3 prior lines; Must have failed treatment with an IMiD, PI, and anti-CD38 therapy
4. Measurable disease per the IMWG response criteria
5. Adequate marrow and organ function without transfusion or growth factor support within 7 days prior to screening
6. Willing and able to undergo bone marrow aspirate and biopsy per protocol

Exclusion Criteria:

1. Inability to comply with study and follow-up procedures
2. History of clinically significant primary amyloidosis, plasma cell leukemia, Waldenstrom macroglobulinemia or myelodysplastic syndrome
3. Received chemotherapy, biologics, or small molecule therapy within 21 days or 5 half-lives, whichever is shorter
4. Use of any non-approved or investigational agent ≤ 4 weeks prior to the first dose of study drug.
5. Received last prior anti-CD38 monoclonal antibody treatment within 28 days before first planned dose of the study drug
6. Current Grade > 1 toxicity, with the exception of Grade 2 peripheral neuropathy, alopecia, or toxicities from prior anti-tumor therapy that are considered irreversible
7. Large-field radiotherapy within 28 days prior to Day 1 (radiation to a single site as concurrent therapy is allowed)
8. Prior autologous stem cell transplant within 180 days prior to Day 1
9. Prior allogeneic stem cell transplant