For Healthcare Professionals

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of XmAb24306 in Combination With Cevostamab in Participants With Relapsed/Refractory Multiple Myeloma

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About the study

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and activity of XmAb24306 in combination with cevostamab in participants with relapsed/refractory multiple myeloma (R/R MM) who have received a minimum of three prior treatments, including at least one immunomodulatory drug (IMiD), one proteasome inhibitor (PI), and one anti-CD38 monoclonal antibody.
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Who can take part

You may be eligible to participate in the study if you meet the following criteria:

INCLUSION CRITERIA

Inclusion Criteria:

  1. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
  2. Life expectancy of at least 12 weeks
  3. Participants must have received a minimum of 3 prior lines of therapy, including at least one PI, one IMiD, and an anti-CD38 monoclonal antibody.
  4. Documented evidence of progressive disease on or after the last prior therapy, or participants who were intolerant to the last prior therapy.
  5. Measurable disease, as defined by the protocol
  6. Participants agree to follow contraception or abstinence requirements as defined in the protocol

EXCLUSION CRITERIA

Exclusion Criteria:

  1. Any anti-cancer therapy within 3 weeks prior to initiation of study treatment with exception defined by the protocol
  2. Participants with autologous stem cell transplantation (SCT) within 100 days prior to first dose of study treatment
  3. Participants with prior allogeneic SCT or solid organ transplantation
  4. Known history of hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS)
  5. Active or history of autoimmune disease
  6. Participants with current or history of Central Nervous System (CNS) disease, or current CNS involvement by Multiple Myeloma (MM)
  7. Significant cardiovascular disease
  8. Participants with known clinically significant liver disease
  9. Symptomatic active pulmonary disease requiring supplemental oxygen
  10. Known active infection requiring intravenous anti-microbial therapy within 14 days prior to first study drug administration
  11. Any episode of active, symptomatic COVID-19 infection, or requiring treatment with IV antivirals for COVID-19 (not including COVID-19 primary prophylaxis) within 14 days, prior to first study treatment
  12. * Other protocol defined inclusion/exclusion criteria may apply

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Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply


Contact the study center to learn if this study is a good match for you.
Phone iconCall 888-662-6728 (U.S. Only)Email iconEmail Study Center

Study Details


Contition

Multiple Myeloma

Age

18+

Phase

PHASE1

Participants Needed

90

Est. Completion Date

Jan 14, 2027

Treatment Type

INTERVENTIONAL


Sponsor

Genentech, Inc.

ClinicalTrials.gov NCT Identifier

NCT05646836

Study Number

GO43980

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