For Healthcare Professionals

A Study of Nivolumab and Relatlimab in Combination With Bevacizumab in Advanced Liver Cancer

clipboard-pencil

About the study

The purpose of this study is to evaluate the safety and effectiveness of triplet therapy of nivolumab, relatlimab and bevacizumab versus nivolumab and bevacizumab in participants with untreated advanced/metastatic hepatocellular carcinoma (HCC).
user-3

Who can take part

You may be eligible to participate in the study if you meet the following criteria:

INCLUSION CRITERIA

Inclusion Criteria:

  1. Histologically confirmed advanced/metastatic hepatocellular carcinoma (HCC)
  2. Naïve to systemic therapy for advanced/metastatic HCC (prior neo-adjuvant or adjuvant immunotherapy is permitted if recurrence occurs ≥ 6 months after treatment completion and the case is discussed with BMS medical team)
  3. Child-Pugh score of 5 or 6 (ie, Child-Pugh A)
  4. Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

EXCLUSION CRITERIA

Exclusion Criteria:

  1. Known fibrolamellar HCC, sarcomatoid HCC or mixed cholangiocarcinoma and HCC
  2. Prior allogenic stem cell or solid organ transplantation
  3. Untreated symptomatic central nervous system (CNS) metastases
  4. Clinically significant ascites as defined by:

i) Prior ascites that required treatment and requires on-going prophylaxis, or ii) Current ascites requiring treatment

Other protocol-defined inclusion/exclusion criteria apply

pin location

Study Locations

Enter your ZIP code/Postal code/PIN code to locate study sites near you:

How to Apply


Contact the study center to learn if this study is a good match for you.
Phone iconCall 855-907-3286Email iconEmail Study Center

Study Details


Contition

Carcinoma, Hepatocellular

Age

18+

Phase

PHASE1/PHASE2

Participants Needed

162

Est. Completion Date

Dec 15, 2026

Treatment Type

INTERVENTIONAL


Sponsor

Bristol-Myers Squibb

ClinicalTrials.gov NCT Identifier

NCT05337137

Study Number

CA224106

Understanding Clinical Trials


Get answers to your questions about clinical trials.What is clinical research?What does taking part in clinical trials involve?What should I ask the trial doctor?
Vector

Interested?

Sign up to create a personal profile and 
receive news, resources, and alerts 
about clinical trials related to your conditions of interest.