A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With Active, Pemphigus Vulgaris (RESET-PV)

Inclusion Criteria:

1. Confirmed diagnosis of mPV by prior or screening biopsy and prior positive anti- DSG3 antibody ELISA
2. mPV inadequately managed by at least one standard immunosuppressive therapies
3. Active mPV at screening
4. Anti-DSG3 antibody ELISA positive at screening

Inclusion Criteria for CABA-201 sub-study

1. Confirmed diagnosis of PV by prior or screening biopsy and prior positive DSG3 ELISA, IIF, and/or DIF
2. PV inadequately managed by at least one standard immunosuppressive therapy
3. Active PV at screening
4. DSG3 ELISA positive at screening

Exclusion Criteria:

1. Active cutaneous lesions associated with PV that indicates mucocutaneous rather than mucosal-dominant disease
2. Rituximab in last 12 months unless PV symptoms have recently worsened or anti-DSG3 antibody titers have recently increased
3. Prednisone > 0.25mg/kg/day
4. Other autoimmune disorder requiring immunosuppressive therapies
5. Investigational treatment in last 3 months

Exclusion Criteria for CABA-201 sub-study

1. Have paraneoplastic pemphigus or active malignancy (not including non-melanoma skin cancer)
2. Have received rituximab or other anti-CD20 or anti-CD19 therapies in last 12 months unless anti-DSG3 antibody titers have recently increased or PV symptoms have recently worsened
3. Prednisone > 0.25mg/kg/day
4. Other autoimmune disorder requiring immunosuppressive therapies
5. Investigational treatment in last 3 months