A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

Inclusion Criteria:

1. Histologically or cytologically confirmed solid tumors with evidence of metastatic or locally advanced disease not amenable to standard therapy with curative intent.
2. A baseline fresh tumor sample (FFPE) from a metastatic or primary site.
3. Amenable for biopsy (if safe/feasible).
4. Measurable disease as defined by RECIST version 1.1 by radiologic methods.
5. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
6. Life expectancy ≥ 12 weeks, as per investigator.
7. Left ventricular ejection fraction (LVEF) ≥ 50% by echocardiogram (ECHO) or multiple gated acquisition scan (MUGA).
8. Adequate organ function
9. Expansion cohorts: patients with locally advanced unresectable or metastatic disease for the following indications:

SINGLE AGENT:

* SECOND-/THIRD-LINE HNSCC PATIENTS (cohort closed to enrolment): patients who have progressed on or after, or are intolerant to, anti-PD-(L)1 therapy and platinum therapy as monotherapy or in combination with other agents and no previous exposure to EGFR inhibitors. Patients treated with platinum-containing therapy only in the adjuvant setting, or in the context of multimodal therapy for locally advanced disease should have disease progression within 6 months of the last dose of platinum containing therapy. Patients with no more than 2 prior lines of treatment in recurrent or metastatic disease.

1. Human papilloma virus (HPV) status determined by p16 immunohistochemistry (IHC) or molecular HPV test for all oropharyngeal tumors should be reported when available.
2. The eligible HNSCC primary tumor locations are oropharynx, oral cavity, hypopharynx, and larynx.
3. GEA with histologically confirmed EGFR amplification (fluorescence in situ hybridization [FISH] score EGFR/chromosome 7 (CEP7) ratio ≥2.0, or tumor next generation sequencing [NGS] EGFR copy ≥8, or cfDNA ≥2.5, or EGFR IHC H-score ≥200). Cohort closed to enrolment.
4. Patients with other indications must have been previously treated with 1 or 2 lines of the standard approved therapy (when applicable) in the locally advanced/unresectable or metastatic setting. Other indications may considered such as malignant salivary gland tumors. Cohort closed to enrolment.

COMBINATION:

1. FIRST-LINE HNSCC (cohort closed to enrolment): patients eligible to receive pembrolizumab as first-line monotherapy with tumors expressing programmed cell death protein ligand 1 (PD-L1), combined positive score (CPS) ≥1, as determined by a Food and Drug Administration (FDA) approved test in the US, or by an approved equivalent test in other countries; patients should not have previous systemic therapy administered in the recurrent or metastatic setting, although previous systemic therapy as part of multimodal treatment for locally advanced disease is allowed if ended ≥6 months prior to signing the ICF. The eligible HNSCC primary tumor locations are oropharynx, oral cavity, hypopharynx, and larynx. Previous treatments with anti PD-(L)1 or anti-EGFR therapies are not allowed.
2. 2L mCRC (cohort open to enrolment): Patients should have been previously diagnosed with histologically or cytologically confirmed unresectable or metastatic adenocarcinoma of the colon or rectum. Patients must be RAS/RAF WT as determined using NGS on tumor tissue (primary or metastatic) or other appropriate tumor tissue based assay, to be confirmed by the sponsor. Patients must be naive to prior anti-EGFR therapy. Radiographically confirmed disease progression must have occurred during or within 6 months of prior 1L chemotherapy.

* Cohort to be treated with petosemtamab and FOLFIRI: patients should have had only 1 prior chemotherapy regimen for the metastatic setting, consisting of 1L fluoropyrimidine-oxaliplatin-based chemotherapy ± bevacizumab. Note: FOLFOX-based adjuvant treatment would be considered front-line if PD occurred within 6 months of completion of adjuvant therapy.

Exclusion Criteria:

1. Central nervous system metastases that are untreated or symptomatic, or require radiation, surgery, or continued steroid therapy to control symptoms within 14 days of study entry.
2. Known leptomeningeal involvement.
3. Participation in another clinical trial or treatment with any investigational drug within 4 weeks prior to study entry.
4. Any systemic anticancer therapy within 4 weeks or 5 half-lives whichever is shorter of the first dose of study treatment. For cytotoxic agents that have major delayed toxicity ( e.g. mitomycin C,nitrosoureas), or anticancer immunotherapies, a washout period of 6 weeks is required.
5. Requirement for immunosuppressive medication (e.g. methotrexate, cyclophosphamide)
6. Major surgery or radiotherapy within 3 weeks of the first dose of study treatment. Patients who received prior radiotherapy to ≥25% of bone marrow are not eligible, irrespective of when it was received.
7. Persistent grade >1 clinically significant toxicities related to prior antineoplastic therapies (except for alopecia); stable sensory neuropathy ≤ grade 2 NCI-CTCAE v4.03 is allowed.
8. History of hypersensitivity reaction to any of the excipients of petosemtamab, human proteins or any non-IMP treatment required for this study.
9. Uncontrolled hypertension (systolic blood pressure [BP] > 150 mmHg and/or diastolic BP > 100 mmHg) with appropriate treatment or unstable angina.
10. History of congestive heart failure of Class II-IV New York Heart Association (NYHA) criteria, or serious cardiac arrhythmia requiring treatment (except atrial fibrillation, paroxysmal supraventricular tachycardia).
11. History of myocardial infarction within 6 months of study entry.
12. History of prior malignancies with the exception of excised cervical intraepithelial neoplasia or nonmelanoma skin cancer, or curatively treated cancer deemed at low risk for recurrence with no evidence of disease for 3 years.
13. Current dyspnea at rest of any origin, or other diseases requiring continuous oxygen therapy.
14. Patients with a history of interstitial lung disease (e.g., pneumonitis or pulmonary fibrosis) or evidence of ILD on baseline chest computerized tomography (CT) scan.
15. Current serious illness or medical conditions including, but not limited to uncontrolled active infection,clinically significant pulmonary, metabolic or psychiatric disorders.
16. Patients with known infectious diseases:

1. Active hepatitis B infection ((hepatitis B surface antigen [HBsAg] positive) without receiving antiviral treatment. Note: Patients who are HBsAg positive must receive antiviral treatment with lamivudine, tenofovir, entecavir, or other antiviral agents, starting at least ≥7 days before the initiation of the study treatment. Patients with antecedents of hepatitis B (e.g., anti-hepatitis B core (anti-HBc) positive, HBsAg and hepatitis B virus [HBV] DNA negative) are eligible.
2. Positive test for hepatitis C ribonucleic acid (HCV) RNA). Note: Patients in whom HCV infection resolved spontaneously (i.e., positive HCV antibodies without detectable HCV -RNA), or who achieved a sustained response after antiviral treatment and show absence of detectable HCV RNA ≥6 months (with the use of interferon [IFN]-free regimens) or ≥ 12 months (with t the use of IFN-based regimens) after cessation of antiviral treatment, are eligible.
3. Pregnant or breastfeeding patients; patients of childbearing potential must use highly effective contraception methods prior to study entry, for the duration of study participation, and for 6 months after the last dose of MCLA-158.