[No standalone website (unbranded, no questionnaire)] A Study of Subjects With Psoriatic Arthritis to Investigate the Effectiveness of Adalimumab Introduction Compared With Methotrexate Dose Escalation (CONTROL)

How to apply

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Study’s contact

Call center

(+1) 866-867-7178

Email address

clinicaltrials@novonordisk.com

Condition

Diabetes Mellitus, Type 2

Treatment type

Interventional

Investigational product

Insulin 287

Phase

Phase 1

Sponsor

Novo Nordisk A/S

ClinicalTrials.gov identifier

NCT03945656

Study number

NN1436-4462

Understanding clinical trials

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About the study

This study is comparing the effect of a long-acting insulin analogue (insulin 287) with insulin glargine (Lantus®) in subjects with type 2 diabetes. In addition, the study is looking at symptoms of low blood sugar, awareness of low blood sugar and the time and amount of glucose needed to recover from low blood sugar after injecting 2 and 3 times the basal dose of insulin 287 and glargine. The purpose of the study is to make a once-weekly injectable basal insulin treatment for people with type 2 diabetes. Participants will get insulin 287 as well as insulin glargine - which treatment any participant gets first is decided by chance. Insulin 287 is a new medicine; insulin glargine can already be prescribed. The study medicines will be in a pen, and must be injected with a needle in the thigh once per day (insulin glargine) or once per week (insulin 287). The study will last for minimum 3 months and up to approximately 6 months. Participants will have 21 clinic visits and at least 2 phone calls with the study doctor. The participants' health will be monitored carefully and blood samples will be taken at the clinic visits.

Who can take part?

You may be eligible to participate in the study if you meet the following criteria:

Inclusion criteria
  1. Male or female, aged between 18 and 72 years (both inclusive) at the time of signing informed consent.
  2. Body mass index between 18.5 and 37.9 kg/m^2 (both inclusive).
  3. Diagnosed with type 2 diabetes mellitus greater than or equal to 180 days prior to the day of screening.
  4. Glycosylated haemoglobin type A1c (HbA1c) less than or equal to 9.0% (less than or equal to 74 mmol/mol) at screening.
  5. Current total daily insulin treatment between 0.2 and 1.0 U/kg/day (both inclusive).
Exclusion criteria
  1. Known or suspected hypersensitivity to trial products or related products.
  2. Female who is pregnant, breast-feeding or intends to become pregnant or is of child-bearing potential and not using an adequate contraceptive method.
  3. Presence or history of any clinically relevant respiratory, metabolic, renal, hepatic, gastrointestinal, endocrinological conditions (except conditions associated with diabetes mellitus).

For a full list of inclusion/exclusion criteria, please visit ClinicalTrials.gov

Study locations

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How to apply

Determine if a study site for this clinical trial is near you. Contact the study to apply.

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