[No standalone website (unbranded, no questionnaire)] A Study of Subjects With Psoriatic Arthritis to Investigate the Effectiveness of Adalimumab Introduction Compared With Methotrexate Dose Escalation (CONTROL)

How to apply

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Study’s contact

Call center

1-888-669-6682

Email address

Novartis.email@novartis.com

Condition

Wounds and Injuries

Treatment type

Interventional

Investigational product

LNA043

Phase

Phase 2

Sponsor

Novartis

ClinicalTrials.gov identifier

NCT03275064

Study number

CLNA043X2202

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About the study

The purpose of this two-part study is to assess the efficacy, safety and tolerability of multiple intra-articular (i.a.) injections of LNA043 in regenerating the articular surface in patients with cartilage lesions of the knee (Part A) and knee osteoarthritis (Part B).

Who can take part?

You may be eligible to participate in the study if you meet the following criteria:

Inclusion criteria
  1. BMI) <30 kg/m2 at screening, for patients with BMI >30 but ≤ 33kg/m2, eligibility will be decided by consultation with the sponsor. - Patient has a symptomatic, single, articular cartilage defect of one knee, grade II or IIIA according to the ICRS classification, localized to either the femoral condyles/femoral trochlea or to the patella, based on MRI or arthroscopy performed within 9 months before screening visit and confirmed by screening 3T MRI. - Patient has an onset of pain and impairment of function between two (
  2. 2) months and two (
  3. 2) years before screening. - Patient reports a KOOS (sports and recreational activities
  4. subscale) score of ≤ 60 at both screening and Day 1.

For a full list of inclusion/exclusion criteria, please visit ClinicalTrials.gov

Study locations

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How to apply

Determine if a study site for this clinical trial is near you. Contact the study to apply.

Find a Study Site